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Undergo periodic bone density testing to assess response to therapy.Notify their dentists, surgeon, and other healthcare providers of ibandronate therapy and have regular routine dental examinations and cleanings.Patient should tell their doctor if they are taking any new medications, including an antibiotic, a diuretic or “water pill”, or a non-steroidal anti-inflammatory medicine (NSAIDS).This includes drinking at least 2 glasses of fluid such as water within a few hours prior to the infusion. Patient should eat and drink normally on the day of treatment.The current recommended daily intake of calcium is 1200 mg in divided doses and vitamin D 800 IU to 1000 IU daily, and all patients should be instructed on the important of maintaining serum calcium levels. Adequate calcium and vitamin D supplementation is important in patients with osteoporosis.Monitor patient post-infusion as per the Infusion Clinic standard operating procedure and once stable remove the IV.Īdditional Managing Infusion Reactions and Considerations.Acetaminophen after administration may reduce the incidence of acute reaction (eg, arthralgia, fever, flu-like symptoms, myalgia). Patients must be appropriately hydrated prior to treatment.Infuse in a line separate from other medications. line with 10 mL NS flush following infusion. Solution should NOT come into contact with any calcium or other divalent-cation containing solutions.Zoledronic acid should be infused intravenously over no less than 15 minutes at a constant rate.
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Zoledronic acid should be stored at 25 ☌ and is stable for 24 hours at 2 ☌-8 ☌ after opening.Zoledronic acid comes as 5mg in a 100mL ready-to-infuse solution.Informed verbal consent with a teaching sheet given.Discussion with patients who may be considering conceiving in the future and/or breastfeeding should be had prior to initiating.Patient has not already had Zometa within one year.Patient ordered to drink two glasses of water 2 hours before infusion.Tylenol ordered before and after first dose to prevent acute phase reaction.Caution should be used in patients with aspirin sensitive asthma.Calcium levels should be closely monitored for hypocalcemia.Caution should be used if patient is on a loop diuretic.Renal panel within 2-4 weeks pre-infusion and 10-14 days post ordered.On calcium/ Vitamin D 1200mg/800IU daily, in divided doses.The recommended dose is a 5 mg infusion for the treatment of Paget’s disease of bone.In patients with osteoporosis, the current recommended daily intake of calcium is 1200 mg in divided doses and vitamin D 800 IU to 1000 IU daily.Intravenous zoledronic acid is given for the prevention of osteoporosis as 5mg once every 2 years.Intravenous zoledronic acid for treatment of postmenopausal osteoporosis, treatment to increase bone mass in men with osteoporosis, and treatment and prevention of glucocorticoid-induced osteoporosis is 5mg per 100mL once every 12 months.Paget’s disease of bone in males and females - Treatment of Paget's disease of bone in men and women.Glucocorticoid induced osteoporosis - treatment and prevention of glucocorticoid-induced osteoporosis.Postmenopausal osteoporosis: Prevention of male Osteoporosis - treatment to increase bone mass in men with osteoporosis.Postmenopausal osteoporosis: Prevention of female Osteoporosis - treatment and prevention of postmenopausal osteoporosis.Bisphosphonates specifically act on bone cells (osteoclasts) to inhibit bone resorption and turnover activity and reduce progressive bone loss and risk for fracture.įinancial Assistance FDA-Approved Indications Bone is a living tissue constantly being remodeled. Unlike other common bisphosphonates that are taken by mouth, Reclast bypasses the stomach because it is an infusion into the bloodstream. ZOLEDRONIC ACID (Reclast) Zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or Paget's disease.